Precautions

Tiazac Description. Tiazac® (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (+)-cis-.

What type of drug is tiazac?

Generic diltiazem extended-release capsules, even if they are the same strength, cannot be substituted for one another if they have different Orange Book codes. Therefore, generics for Cardizem CD cannot legally be substituted with generics for Tiazac since they have different Orange Book codes. Hello and thank you for submitting your question!

Can I use generic diltiazem CD instead of generic tiazac?

This is somewhat of an unusual situation since both of these brand name drugs (Cardizem CD and Tiazac) contain the same active ingredient (diltiazem), but they are nonetheless different drug products, each with unique properties.

What is the difference between Cardizem CD and tiazac?

Subsequent titration to higher or lower doses may, however, be necessary and should be initiated as clinically indicated. Tiazac (diltiazem hydrochloride) Extended-Release Capsules may also be administered by carefully opening the capsule and sprinkling the capsule contents on a spoonful of applesauce.

How is tiazac (diltiazem hydrochloride) administered?

What is the generic for Tiazac?

TAZTIA XT (diltiazem hydrochloride capsule, extended release;oral)

Is tiazac the same as diltiazem?

Tiazac (diltiazem hydrochloride) is a calcium channel blocker used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders. Tiazac is available in generic form.

Are tiazac and Cardizem the same?

Comments: These two formulations are not interchangeable. Tiazac® XC is a tablet, whereas Cardizem® CD is a capsule. The patient may have perceived that they were two different medications, so it was never questioned by the patient.

What is an alternative to diltiazem?

Diltiazem Alternatives ComparedDiltiazemLisinoprilBrand NamesCardizem, Cardizem CD, Cardizem LA, Cartia XT, Dilacor XR, Dilt-XR, Diltia XT, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltzac, Matzim LA, Taztia XT, Tiadylt ER, Tiazac View morePrinivil, Qbrelis, Zestril41 more rows

What is the generic brand for diltiazem?

Diltiazem oral capsule is available as both a generic and brand-name drug. Brand names: Cardizem CD, and Taztia XT. It is available as an extended-release capsule.

What is the best time of day to take Tiazac?

This medication should be taken once daily, at bedtime. It may be taken with or without food, but you should take the medication in the same way every time (always with food or always without food). Swallow the tablet whole with a glass of water – do not crush or chew the tablet.

How do I stop taking Tiazac?

Do not stop taking this medication without first talking to your doctor. If you stop taking this medicine suddenly, your condition may become worse. Tiazac may be only part of a complete program of treatment that also includes diet, exercise, and other medications.

Does tiazac cause weight gain?

Tell your doctor right away if you have any serious side effects, including: fainting, new or worsening symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain), slow/irregular/pounding/fast heartbeat, mental/mood changes (such as depression, agitation …

Is diltiazem hard on the kidneys?

Diltiazem can damage the kidneys, heart, and blood vessels of the brain, resulting in heart failure, kidney failure, or stroke. The risk of heart attacks may increase due to high blood pressure.

What are the best calcium channel blockers?

Some calcium channel blockers can also slow the heart rate, which can further lower blood pressure….Examples of calcium channel blockersAmlodipine (Norvasc)Diltiazem (Cardizem, Tiazac, others)Felodipine.Isradipine.Nicardipine.Nifedipine (Procardia)Nisoldipine (Sular)Verapamil (Calan SR, Verelan)

Which is safer diltiazem or metoprolol?

Conclusions: Diltiazem was more effective in achieving rate control in ED patients with AFF and did so with no increased incidence of adverse effects.

Which has less side effects amlodipine or diltiazem?

While amlodipine is more potent than diltiazem in reducing systolic blood pressure, it causes more vasodilator side effects.

What are the side effects of Tiazac?

Dizziness, lightheadedness, weakness, nausea, flushing, constipation, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To lower the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

What is the difference between diltiazem and Cardizem?

These medicines both contain an active ingredient called diltiazem hydrochloride. The difference between these is that Cardizem CD is designed to release the active ingredient slowly so that it works over 24 hours and can be taken once a day (CD stands for “controlled delivery”).

Is Tiazac extended-release?

Tiazac capsules contain diltiazem hydrochloride in extended-release beads at doses of 120, 180, 240, 300, 360 and 420 mg.

How do I stop taking Tiazac?

Do not stop taking this medication without first talking to your doctor. If you stop taking this medicine suddenly, your condition may become worse. Tiazac may be only part of a complete program of treatment that also includes diet, exercise, and other medications.

How toxic is diltiazem?

The toxic dose in man is not known. Due to extensive metabolism, blood levels after a standard dose of diltiazem can vary over tenfold, limiting the usefulness of blood levels in overdose cases. There have been 29 reports of diltiazem overdose in doses ranging from less than 1 g to 10.8 g. Sixteen of these reports involved multiple drug ingestions. Twenty-two reports indicated patients had recovered from diltiazem overdose ranging from less than 1 g to 10.8 g. There were seven reports with a fatal outcome; although the amount of diltiazem ingested was unknown, multiple drug ingestions were confirmed in six of the seven reports.

What is the chemical structure of diltiazem?

It is soluble in water, methanol and chloroform and has a molecular weight of 450.98. Tiazac capsules contain diltiazem hydrochloride in extended-release beads at doses of 120, 180, 240, 300, 360 and 420 mg.

What is diltiazem in animal models?

In animal models, diltiazem interferes with the slow inward (depolarizing) current in excitable tissue. It causes excitation-contraction uncoupling in various myocardial tissues without changes in the configuration of the action potential.

How much diltiazem is bound to plasma proteins?

In vitro binding studies show diltiazem hydrochloride is 70% to 80% bound to plasma proteins. Competitive in vitro ligand binding studies have also shown diltiazem hydrochloride binding is not altered by therapeutic concentrations of digoxin, hydrochlorothiazide, phenylbutazone, propranolol, salicylic acid, or warfarin.

How is diltiazem metabolized?

Diltiazem hydrochloride is extensively metabolized by the liver and excreted by the kidneys and in bile. As with any drug given over prolonged periods, laboratory parameters of renal and hepatic function should be monitored at regular intervals. The drug should be used with caution in patients with impaired renal or hepatic function. In subacute and chronic dog and rat studies designed to produce toxicity, high doses of diltiazem were associated with hepatic damage. In special subacute hepatic studies, oral doses of 125 mg/kg and higher in rats were associated with histological changes in the liver which were reversible when the drug was discontinued. In dogs, doses of 20 mg/kg were also associated with hepatic changes; however, these changes were reversible with continued dosing.

What were the events that occurred after diltiazem overdose?

Events observed following diltiazem overdose included bradycardia, hypotension, heart block, and cardiac failure. Most reports of overdose described some supportive medical measure and/or drug treatment. Bradycardia frequently responded favorably to atropine as did heart block, although cardiac pacing was also frequently utilized to treat heart block. Fluids and vasopressors were used to maintain blood pressure, and in cases of cardiac failure, inotropic agents were administered. In addition, some patients received treatment with ventilatory support, activated charcoal, and/or intravenous calcium. Evidence of the effectiveness of intravenous calcium administration to reverse the pharmacological effects of diltiazem overdose was conflicting.

How long does diltiazem stay in your system?

Only 2% to 4% of unchanged diltiazem appears in the urine. The plasma elimination half-life of diltiazem is approximately 3.0 to 4.5 hours. Drugs which induce or inhibit hepatic microsomal enzymes may alter diltiazem disposition. Therapeutic blood levels of diltiazem appear to be in the range of 40 to 200 ng/mL. There is a departure from linearity when dose strengths are increased; the half-life is slightly increased with dose.

How much titration for angina?

Individual patients may respond to higher doses of up to 540 mg once daily. When necessary, titration should be carried out over 7 to 14 days.

Can you swallow tizac without chewing?

Tiazac (diltiazem hydrochloride) Extended-Release Capsules may also be administered by carefully opening the capsule and sprinkling the capsule contents on a spoonful of applesauce. The applesauce should be swallowed immediately without chewing and followed with a glass of cool water to ensure complete swallowing of the capsule contents. The applesauce should not be hot, and it should be soft enough to be swallowed without chewing. Any capsule contents/applesauce mixture should be used immediately and not stored for future use. Subdividing the contents of a Tiazac (diltiazem hydrochloride) Extended-Release Capsule is not recommended.

Can diltiazem be used with nitrates?

2. Prophylactic Nitrate Therapy: Diltiazem hydrochloride may be safely coadministered with short- and long-acting nitrates. 3. Beta-blockers: (See WARNINGS and PRECAUTIONS .) 4. Antihypertensives: Diltiazem hydrochloride has an additive antihypertensive effect when used with other antihypertensive agents. Therefore, the dosage of diltiazem …

Can you switch to Tiazac?

Hypertensive or anginal patients who are treated with other formulations of diltiazem can safely be switched to Tiazac capsule s at the nearest equivalent total daily dose. Subsequent titration to higher or lower doses may, however, be necessary and should be initiated as clinically indicated.

What is therapeutic equivalence?

This concept of ‘ therapeutic equivalence ‘ can be a little confusing, but basically, it is a system that exists that links drugs (namely brand and generic products) based on their ‘bioequivalence’ to each other (bioequivalence in this sense is defined as two drugs having the same rate and extent of absorption). Drugs that have the same rate and extent of absorption should, in theory, exhibit the same clinical effect.

When a pharmacy substitutes a generic drug for a brand name that your doctor has written for, the generic?

When your pharmacy substitutes a generic drug for a brand name that your doctor has written for, the generic drug must be classified as ‘therapeutically equivalent’.

Can you use generic diltiazem with tizac?

Therefore, generics for Cardizem CD cannot legally be substituted with generics for Tiazac since they have different Orange Book codes.

Is Cardizem CD equivalent to Tiazac?

There are multiple diltiazem extended-release capsule formulations available, including Cardizem CD and Tiazac. They are not all considered equivalent to one another.

Can a pharmacy fill a generic?

Most states have ‘generic substitution laws’ that require pharmacies to dispense a ‘ therapeutically equivalent ‘ generic product for a brand name one. There are exceptions to this, but in general, if your doctor writes you a prescription for a brand name product, it will be filled generically (if one is available).

Is CD and Tiazac the same?

This is somewhat of an unusual situation since both of these brand name drugs (Cardizem CD and Tiazac) contain the same active ingredient (diltiazem), but they are nonetheless different drug products, each with unique properties.

Is diltiazem 360 mg generic?

You are correct that both of the products you mention in your question are diltiazem 360 mg extended-release capsules. However, they are each generic versions for different brand name drugs. ‘Diltiazem 360 mg extended-release capsules (NDC 47335-0679-81)’ is the generic for the brand name drug Cardizem CD while the other diltiazem 360 mg …

What is the difference between diltiazem and cobicistat?

Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate: (Moderate) Monitor blood pressure and heart rate if coadministration of diltiazem with cobicistat is necessary. Diltiazem is a CYP3A4 substrate and cobicistat is a strong CYP3A4 inhibitor.

How is diltiazem administered?

Diltiazem is administered orally and intravenously. It is widely distributed throughout the body and into maternal breast milk in equal concentrations to those achieved in serum. Roughly 70% to 80% of the circulating drug is bound to plasma proteins.

How long does it take for diltiazem to work?

The onset of action occurs within 1 hour for immediate-release products and within 2 to 3 hours for the sustained-release formulations of the drug. Time to peak effect is 2 to 3 hours for the immediate-release and 6 to 11 hours for the sustained-release formulations. The mean AUC of diltiazem is increased 50% in elderly vs. young subjects following oral administration. Grapefruit juice (food) appears to have no effect on diltiazem bioavailability, although the drug half-life is increased slightly.

How long does diltiazem stay in your system?

The half-life ranges from 3.5 to 9 hours and is usually 4 to 6 hours. About 2% to 4% of the drug is excreted unchanged in the urine, with the remainder excreted in the bile and urine.

Is diltiazem safe for heart failure?

In geriatric versus younger adult subjects, the half-life of diltiazem is prolonged, and clearance is decreased, with a potential increase in risk for drug accumulation and toxicity. In general, initiate at the lower end of the adult dosage range in the older adult and adjust diltiazem dosage based on clinical response. [28277] According to the Beers Criteria, non-dihydropyridine calcium channel blockers including diltiazem are considered potentially inappropriate medications (PIMs) in geriatric patients with heart failure due to the potential for fluid retention and exacerbation of the condition; however, avoidance is only recommended in heart failure patients with a reduced ejection fraction. [63923] The federal Omnibus Budget Reconciliation Act (OBRA) regulates medication use in residents of long-term care facilities; individualize the antihypertensive regimen to achieve the desired outcome while minimizing adverse effects. Antihypertensives may cause dizziness, postural hypotension, fatigue, and there is an increased risk for falls. Calcium channel blockers may cause peripheral edema and clinically significant constipation; some agents may cause generalized aching, headache, and muscle pain. Antiarrhythmic agents can have serious adverse effects (e.g., changes in mental function, appetite, behavior, heart function, or increased risk for falls) in older individuals. [60742]

Can diltiazem be delayed?

Patients with hepatic disease, such as cirrhosis or hepatic failure, can experience a delayed clearance of diltiazem and can be at greater risk for accumulation and toxicity. Diltiazem pharmacokinetics and dosage requirements are not altered by renal impairment.

Is diltiazem contraindicated for AV block?

Due to its inhibitory effects on AV node conduction, diltiazem is contraindicated in patients with preexisting second- or third-degree AV block or previous conduction abnormalities. Diltiazem should be used with extreme caution in patients taking beta-adrenergic blocking agents.

What is Cardizem LA?

Cardizem LA is a brand name of diltiazem, approved by the FDA in the following formulation (s):

Is Cardizem LA generic?

A generic version of Cardizem LA has been approved by the FDA. However, this does not mean that the product will necessarily be commercial ly available – possibly because of drug patents and/or drug exclusivity . The following products are equivalent to Cardizem LA and have been approved by the FDA: