How many milligrams of statin are in a dose?
Statin Dose Intensity and Equivalency Chart* Statin Intensity %LDL-C Reduction HMG-CoA Reductase Inhibitor Rosuvastatin Atorvastatin Pitavastatin Simvastatin Lovastatin Pravastatin Fluvastatin High-Intensity (lowers LDL-C ≥ 50%) 63 40 mg ($196) 62 61 60 80mg ($9 gen, $ 236. br) 59 58 56 20 mg 54 ($196) 52
What is the highest dose of statin to lower LDL?
Statin Dose Intensity and Equivalency Chart* Statin Intensity %LDL-C Reduction HMG-CoA Reductase Inhibitor Rosuvastatin Atorvastatin Pitavastatin Simvastatin Lovastatin Pravastatin Fluvastatin High- Intensity (lowers LDL-C ≥ 50%) 63 40 mg ($196) 62 61 60 80mg ($9 gen, $ 236
What is a high intensity statin for a 40 75 year old?
Patients age 40-75 without diabetes or CVD, but with LDL-C 70-189 and 10-year risk >7.5%, should consider a moderate-to-high intensity statin. + Atorvastatin 40-80mg considered high intensity. Avoid atorvastatin with glecaprevir/pibrentasvir (Mavyret) for HCV. ** 10 mg ezetimibe § plus 10, 20, 40 or 80mg simvastatin.
What is the ACC/AHA classification of intensity for statins?
Table 1Statin Dosing and ACC/AHA Classification of Intensity View in own window Statin Dosage Low-intensity (LDL-C reduction <30%) Moderate-intensity
What is equivalent to atorvastatin?
NAPLEX Question of the Week: Statin EquivalenciesDrugEquivalent Dose (mg) by Intensity LDL reductionRosuvastatin (Crestor)5-10Atorvastatin (Lipitor)10-20Simvastatin (Zocor)20-40Lovastatin (Mevacor)40-802 more rows•Nov 1, 2021
Can you interchange statins?
As case studies indicate that after withdrawal of a statin cholesterol levels can double within 2 weeks, the MARC recommends that when switching a patient from one statin to another, the changeover should be managed in much the same way as statin therapy is initiated.
What is simvastatin equivalent to atorvastatin?
In controlled dosing studies, simvastatin 40 mg and atorvastatin 10 mg and 20 mg are equally effective. Simvastatin 40 mg lowers plasma concentrations of low density lipoprotein (LDL) cholesterol by 3% more than atorvastatin 10 mg and 4% less than atorvastatin 20 mg.
What is the lowest mg for statins?
For the purposes of this definition, the lowest daily starting doses of statins are proposed as rosuvastatin 5 mg, atorvastatin 10 mg, simvastatin 20 mg, lovastatin 20 mg, pravastatin 40 mg, fluvastatin 40 mg, and pitavastatin 2 mg.
Is it OK to switch from Lipitor to Crestor?
Sept. 5, 2007 — Patients who switch from the statin drug Lipitor to a generic version of another statin may be more likely to suffer strokes, heart attacks, and death, a new study from Lipitor manufacturer Pfizer shows.
Is it okay to switch from atorvastatin to simvastatin?
A large proportion of patients who switch from atorvastatin to simvastatin are prescribed doses that are not therapeutically equivalent, and these patients were significantly less likely to meet LDL-C treatment goals compared with patients who remained on atorvastatin.
What is the best statin for the elderly?
Atorvastatin or fluvastatin are usually recommended because there is no need to adjust the dose according to the glomerular filtration rate [28]. In patients without diagnosed atherosclerotic cardiovascular disease, it is indicated a moderate dose of statin, such as atorvastatin 20 mg daily [28].
Is atorvastatin 20 mg the same as simvastatin 20 mg?
No strong head-to-head trials comparing atorvastatin and simvastatin have been conducted. However, atorvastatin is considered a more potent drug than simvastatin. In one recent comparative study, atorvastatin was found to be more effective at lowering LDL cholesterol (LDL-C) than simvastatin.
Is there a statin that doesn’t cause muscle pain?
There are two: alirocumab (Praluent®) and evolocumab (Repatha®). These powerful drugs can lower LDL to rock-bottom levels without triggering muscle pain. A word of warning: Never stop taking a statin without your doctor’s guidance. “It can greatly increase your chance of having a heart attack,” Dr.
Is 5 mg statin effective?
This paper reviews key clinical results for a new agent, rosuvastatin. The data show that rosuvastatin 5 mg is highly effective in lowering LDL-C to recommended levels for most patients (mean reductions ranging from 42 to 52%).
Can you stop taking statins Once you start?
Do not suddenly stop taking your prescribed medication without talking with your doctor first. If you have side effects from the medication, your doctor might adjust your dosage or recommend a different statin or other combination of medications.
Can you take statins every other day?
Background: Statins are generally well tolerated, but some patients discontinue therapy secondary to adverse effects. Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population.
Can I change from rosuvastatin to atorvastatin?
Abstract. Background: Now that generic atorvastatin has become available, a process of switching from rosuvastatin to atorvastatin may occur and could persist until the patent on branded rosuvastatin expires. It is important to understand the impact that such therapy may have on patients’ cardiovascular (CV) health.
Can I take atorvastatin instead of rosuvastatin?
Trials in patients with hypercholesterolaemia have shown that rosuvastatin is more effective than atorvastatin at reducing LDL-C and achieving US and/or European LDL-C goals over treatment periods ranging from 6 to 52 weeks [25-30].
Is there a better statin than atorvastatin?
This study compiled results from 50 randomized, clinical trials, and compared other statin drugs like fluvastatin, pravastatin, rosuvastatin, and lovastatin. Rosuvastatin had the highest potency for lowering LDL levels in the study.
Is rosuvastatin 10 mg the same as atorvastatin 20 mg?
Conclusion. In high-risk patients with hypercholesterolemia, rosuvastatin 10 mg was more efficacious than atorvastatin 20 mg at reducing LDL-C, enabling LDL-C goal achievement and improving other lipid parameters. Both treatments were well tolerated.
Statins (HMG-CoA Reductase Inhibitors)
‘ — ‘ Signifies that equivalent tablet size is not available (comparable dose is either too high or too low)
Reference (s)
National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
