Calculation of Oral Morphine Equivalents (OME)
| Opioid | Route | Dose in commonly used Unit | Multiplication Factor to get OME | Oral Morphine Equivalents |
| Alfentanil | IV | mg | 30 | 30mg |
| Buprenorphine | PO/ SL/ buccal | 1mg | 30 | 30mg |
| Buprenorphine | IV/IM | 1mg | 100 | 100mg |
| Buprenorphine | Transdermal | 1 mcg/h | 75 | 1.8mg/d (75mcg/h) |
Aug 13 2022
How do you calculate morphine equivalents?
- Calculate the 24 hour current dose: 90mg q 12 = 180 mg Morphine/24 hours
- Use the oral to parenteral equianalgesic ratio: 30 mg PO Morphine = 10 mg IV Morphine
- Calculate new dose using ratios: 180/30 x 10 = 60 mg IV Morphine/24 hours or 2.5 mg/hour infusion
How to determine morphine equivalents?
Morphine Equivalent Dosing RxPerts Industry Insights 3 Do the Math Milligram Morphine Equivalent (MME) is a value assigned to opioids to represent their relative potencies. MME is determined by using an equivalency factor to calculate a dose of morphine that is equivalent to the ordered opioid. Daily MED is the sum of
Is morphine stronger than Percocet?
stronger than morphine. 1.5 1x morphine Oxycodone, the opioid in Oxycontin, Percocet and Percodan, as well as other medicines, is about 50 percent stronger than morphine. Oxycodone is commonly…
What is the maximum daily dose of morphine?
Usual dose 100 mg every 12 hours; up to 600 mg every 12 hours, higher dose may be required for some patients (occasionally more is needed); for management of breakthrough pain and other general advice, see Pain management with opioids under Prescribing in palliative care. Initially 5 mg every 4 hours.
What is a MED conversion calculator?
The Morphine Equivalent Dose ( MED) conversions calculator allows a clinician to generate an equivalent dose of morphine for a patient taking one or more common opioids. This tool also provides precise control over methadone conversions as well.
How long does it take for fentanyl to release from the skin?
Example: fentanyl will continue to be released from the skin 12 to 36 hours after removal of the patch. Residual effects from discontinued long-acting formulations should also be assessed before converting a patient to a new opioid. Review the concept of incomplete cross-tolerance:
Is equianalgesic ratio crude?
Published equianalgesic ratios are considered crude estimates at best and therefore it is imperative that careful consideration is given to individualizing the dose of the selected opioid. Dosage titration of the new opioid should be completed slowly and with frequent monitoring.
Why do you switch analgesics?
There may be several possible reasons to switch analgesics including: drug cost, availability, lack of effectiveness of the current drug, or to minimize adverse effects . This tool also provides precise control over methadone conversions as well as corrections for incomplete cross-tolerance.
How long does it take for fentanyl to release from the skin?
Example: fentanyl will continue to be released from the skin 12 to 36 hours after removal of the patch. Residual effects from discontinued long-acting formulations should also be assessed before converting a patient to a new opioid.
Is equianalgesic ratio crude?
Published equianalgesic ratios are considered crude estimates at best and therefore it is imperative that careful consideration is given to individualizing the dose of the selected opioid. Dosage titration of the new opioid should be completed slowly and with frequent monitoring.
