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Equivalence Study of Dorzolamide 2% Eye Drops Solution.
| Condition or disease | Intervention/treatment | Phase |
|---|---|---|
| Open Angle Glaucoma Ocular Hypertension | Drug: Dorzolamide 2 % eye drops solution | Phase 3 |
Precautions
Ophthalmic solution containing Dorzolamide 2% (20 mg/mL) equivalent to 22.3 mg/mL of Dorzolamide hydrochloride. Dorzolamide hydrochloride ophthalmic solution is contraindicated in patients who are hypersensitive to any component of this product [see Warnings and Precautions (5.1) ].
What is the equivalent of dorzolamide hydrochloride in ophthalmic solution?
It is a combination of dorzolamide hydrochloride and timolol maleate. It may be used when a beta blocker, like timolol, is not sufficient alone. It is used as an eye drop. Common side effects include eye discomfort, eye redness, taste changes, and blurry vision. Serious side effects may include allergic reactions…
What is dorzolamide hydrochloride ointment used for?
Dorzolamide Description. The pH of the solution is approximately 5.6, and the osmolarity is 260-330 mOsM. Each mL of Dorzolamide Hydrochloride Ophthalmic Solution 2% contains 20 mg Dorzolamide (22.3 mg of Dorzolamide hydrochloride). Inactive ingredients are hydroxyethyl cellulose, mannitol, sodium citrate dehydrate,…
What is the osmolarity of dorzolamide?
Each mL of Dorzolamide Hydrochloride Ophthalmic Solution 2% contains 20 mg Dorzolamide (22.3 mg of Dorzolamide hydrochloride). Inactive ingredients are hydroxyethyl cellulose, mannitol, sodium citrate dehydrate, sodium hydroxide (to adjust pH) and purified water.
What are the ingredients in dorzolamide hydrochloride 2%?
Is there a substitute for dorzolamide?
Essentially, brimonidine 0.1% (Alphagan P, Allergan) is often a reasonable substitution for dorzolamide, while brimonidine-timolol (Combigan, Allergan) is an ideal substitution for dorzolamide-timolol shortages, assuming no brimonidine allergy.
Is there a generic for dorzolamide?
Cosopt (dorzolamide / timolol) is available as a generic medication and may be significantly cheaper compared to the brand version.
Is latanoprost and dorzolamide the same?
Conclusion: Latanoprost was superior to dorzolamide in reducing the intraocular pressure, judged from the effect on mean intraocular pressure. The once daily dose in the evening ensures better compliance and the problem of hyperpigmentation of the iris were not encountered.
Is dorzolamide the same as timolol?
Dorzolamide and timolol is used for patients whose eye condition has not responded to another medication. Dorzolamide is in a class of medications called topical carbonic anhydrase inhibitors. Timolol is in a class of medications called topical beta blockers.
Why is there a dorzolamide shortage?
Reason for the Shortage Bausch Health had dorzolamide and timolol ophthalmic solution on shortage due to manufacturing delays.
What is the safest eye drop for glaucoma?
Next came apraclonidine, brand name Iopidine, marketed by Alcon. I did much of the clinical work on apraclonidine, a relatively selective alpha-2 agonist. It is probably the safest drug we have seen so far in the therapy of glaucoma.
Is dorzolamide the same as brimonidine?
Conclusions: This study suggests that brimonidine purite and dorzolamide each given twice daily have similar efficacy in primary open angle glaucoma or ocular hypertensive subjects. However, a trend was observed at 10:00 of greater brimonidine purite efficacy compared with dorzolamide.
Can latanoprost and dorzolamide be used together?
Conclusions: The results showed that latanoprost and dorzolamide can be combined successfully to reduce IOP with their additive effects.
Does dorzolamide affect the heart?
dorzolamide and timolol ophthalmic can cause serious breathing problems or heart failure. Get medical help if you have shortness of breath, pounding heartbeats, swelling in your lower legs, or rapid weight gain.
Which is better dorzolamide and timolol?
Conclusion: Two percent dorzolamide (three times daily) was effective and well tolerated in patients with glaucoma or ocular hypertension associated with pseudoexfoliation over the course of 6 months; 0.5% timolol (twice daily) had a greater level of intraocular pressure-lowering activity than did dorzolamide, although …
How long can I use dorzolamide eye drops?
Bottles of eye drops only keep for four weeks once the bottle has been opened, so do not use the drops if the bottle has been open for longer than this. This will help to prevent the risk of eye infections. Single-dose units should be used as soon as the unit is opened.
Why was timolol discontinued?
Reason for the Shortage Bausch Health has Timoptic-XE ophthalmic gel forming solution on shortage due to manufacturing delays. The company discontinued timolol ophthalmic gel forming solution in September 2020.
What is the cash price for dorzolamide?
The cost for dorzolamide ophthalmic ophthalmic solution 2% is around $22 for a supply of 10 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How long can I use dorzolamide eye drops?
Bottles of eye drops only keep for four weeks once the bottle has been opened, so do not use the drops if the bottle has been open for longer than this. This will help to prevent the risk of eye infections. Single-dose units should be used as soon as the unit is opened.
Are azopt and dorzolamide the same?
Azopt is a brand-name medication that’s also available as the generic drug brinzolamide. Trusopt is available as the generic drug dorzolamide. (A generic drug is an exact copy of the active drug in a brand-name medication.) Both Azopt and Trusopt belong to a class of drugs called carbonic anhydrase inhibitors.
Is Trusopt the same as dorzolamide?
Trusopt (dorzolamide) is a carbonic anhydrase inhibitor that reduces the amount of fluid in the eye, which decreases pressure inside the eye, used to treat open-angle glaucoma and other causes of high pressure inside the eye. Trusopt is available in generic form.
What is Dorzolamide?
Pharmacology. Dorzolamide is a human carboanydrase II inhibitor. Inhibition of carboanhydrase in the ciliary processes of the eye decreases aqueous humor secretion supposedly by decreasing the formation rate of bicarbonate ions. This results in reduction in both sodium and fluid transport.
Is cosopt better than latanoprost?
Compared to other products such as latanoprost, both are equally efficacious with regard to lowering intraocular pressure and getting patients to reach their target intraocular pressure. Cosopt, though, is typically less well tolerated than other treatments due to a well documented feeling of ocular burning upon administration.
Does dorzolamide cause eye pain?
Common side effects include eye discomfort, eye redness, taste changes, and blurry vision. Serious side effects may include allergic reactions and heart failure. Use is not recommended in those with asthma, a sulfonamide allergy, or a slow heart rate. Dorzolamide is a carbonic anhydrase inhibitor and timolol is a beta blocker. Both work by decreasing the amount of aqueous humor made by the eye.
How much does Cosopt (dorzolamide / timolol) cost?
Unless there is a specific reason you need the brand, the generic medication will be a better value. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price.
What are the side effects of Cosopt (dorzolamide / timolol)?
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
Can you take dorzolamide if you have kidney problems?
Dorzolamide, one of the ingredients of Cosopt (dorzolamide / timolol), is not recommended for people with poor kidney health. When your kidneys aren’t working well, dorzolamide can build up in the body and cause more side effects. There are not a lot of studies about using dorzolamide when you have liver problems, so you’ll want to be careful about using this medication if you have liver problems. Make sure your provider knows if you have any problems with your kidneys or liver before starting Cosopt (dorzolamide / timolol).
Does timolol cause depression?
Depression is a possible but uncommon side effect of using timolol, one of the medications in Cosopt (dorzolamide / timolol). Cosopt (dorzolamide / timolol) can also cause symptoms that feel like depression, such as fatigue and tiredness.
Can you take Verapamil and Vilanterol together?
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Can medicine cause side effects?
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Is timolol the same as cosopt?
Are Cosopt (dorzolamide / timolol) and timolol the same? Cosopt (dorzolamide / timolol) is a combination of timolol and another medication, dorzolamide. If timolol is not working well enough on its own for your high eye pressure or glaucoma, your provider may switch you to Cosopt (dorzolamide / timolol).
Indications and Usage For Dorzolamide
Dorzolamide is used to treat high pressure inside the eye due to glaucoma (open angle-type) or other eye diseases (such as ocular hypertension).
May Treat: Ocular hypertension · Open angle glaucoma
Brand Names: Trusopt
Drug Class: Ophthalmic – Carbonic Anhydrase Inhibitors
Availability: Prescription Required
Pregnancy: Consult a doctor before using
May Treat: Ocular hypertension · Open angle glaucoma
Brand Names: Trusopt
Drug Class: Ophthalmic – Carbonic Anhydrase Inhibitors
Availability: Prescription Required
Pregnancy: Consult a doctor before using
Lactation: Consult a doctor before using
Driving: May cause drowsiness or dizziness. Use caution
- If available, read the patient package insert
- Wash hands before and after using
- Do not touch tip of open eye drop bottle
- If available, read the patient package insert
- Wash hands before and after using
- Do not touch tip of open eye drop bottle
- May wear contact lenses 15 min. after using drug.
- Wait 10 minutes before other eye medications.
- Take doses regularly, even when feeling well
- May blur vision. Use caution when driving.
- Tell doctor your complete medical history
Dorzolamide Dosage and Administration
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
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The dose is one drop of Dorzolamide Hydrochloride Ophthalmic Solution, USP in the affected eye(s) three times daily. Dorzolamide Hydrochloride Ophthalmic Solution, USP may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five m…
Use in Specific Populations
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Dorzolamide Hydrochloride Ophthalmic Solution is contraindicated in patients who are hypersensitive to any component of this product [see Warnings and Precautions (5.1)].
Overdosage
- Sulfonamide Hypersensitivity
Dorzolamide Hydrochloride Ophthalmic Solution contains Dorzolamide, a sulfonamide; and although administered topically, it is absorbed systemically. Therefore, the same types of adverse reactions that are attributable to sulfonamides may occur with topical administration of Dorzola… - Bacterial Keratitis
There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products. These containers had been inadvertently contaminated by patients who, in most cases, had a concurrent corneal disease or a disruption of the ocular epith…
Dorzolamide Description
- Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Controlled clinical trials: The m… - Post-Marketing Experience
The following adverse reactions have been identified during post-approval use of Dorzolamide Hydrochloride Ophthalmic Solution. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or esta…
Overview
- Oral Carbonic Anhydrase Inhibitors
There is a potential for an additive effect on the known systemic effects of carbonic anhydrase inhibition in patients receiving an oral carbonic anhydrase inhibitor and Dorzolamide Hydrochloride Ophthalmic Solution. The concomitant administration of Dorzolamide Hydrochlori… - High-Dose Salicylate Therapy
Although acid-base and electrolyte disturbances were not reported in the clinical trials with Dorzolamide hydrochloride ophthalmic solution, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., to…
Comparison to other products
- Pregnancy
Risk Summary There are no adequate and well-controlled studies in pregnant women with Dorzolamide Hydrochloride Ophthalmic Solution. Dorzolamide caused fetal vertebral malformations when administered orally to rabbits at 2.5 mg/kg/day (37 times the clinical expos… - Lactation
Risk Summary There are no data on the presence of Dorzolamide Hydrochloride Ophthalmic Solution in human milk, the effects on the breastfed infant, or the effects on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother…
Adverse effects
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Electrolyte imbalance, development of an acidotic state, and possible central nervous system effects may occur. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.
Pharmacology
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Dorzolamide Hydrochloride Ophthalmic Solution, USP is a carbonic anhydrase inhibitor formulated for topical ophthalmic use. Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6- methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active. The specific rotation is [α] 25…
History
Dorzolamide/timolol, sold under the brand name Cosopt among others, is a medication used to treat high pressure inside the eye including glaucoma. It is a combination of dorzolamide hydrochloride and timolol maleate. It may be used when a beta blocker, like timolol, is not sufficient alone. It is used as an eye drop.
Common side effects include eye discomfort, eye redness, taste changes, and blurry vision. Seri…
Society and culture
Despite each of the active ingredients being availed in their own respective formulations, combination formulations are typically more convenient for the patient without sacrificing any quality in therapy. In the case of Cosopt, the combination formulation dosed twice daily provides equivalent treatment to both dorzolamide 2% dosed two times daily and timolol 0.5% dosed three times daily. Specifically, the mean reduction in intraocular pressure was 27.4% for the combinati…
External links
Common adverse effects include temporarily blurred vision, cloudy vision, double vision, temporary burning/stinging/itching of the eye, watery eyes, feeling as if something is in the eye, drooping eyelid, sensitivity to light, cough, flu symptoms, nausea, and stomach pain.
More serious adverse effects include dizziness, slow or irregular heartbeat, muscle weakness, mental/mood changes, and coldness/numbness/pain in the hands or feet.